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KMID : 1195620110040020101
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Clinical and Experimental Otorhinolaryngology
2011 Volume.4 No. 2 p.101 ~ p.104
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The Role of Laryngopharyngeal Reflux as a Risk Factor in Laryngeal Cancer: A Preliminary Report
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Tae Kyung
Jin Bong-Joon
Ji Yong-Bae
Jeong Jin-Hyeok
Cho Seok-Hyun
Lee Seung-Hwan
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Abstract
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Objectives: To evaluate the significance of laryngopharyngeal reflux (LPR) as a risk factor in laryngeal cancer.
Methods: We performed a case-control study with 29 consecutive laryngeal cancer patients who had undergone 24-hour ambulatory double pH monitoring from 2003 to 2006. The control group included 300 patients who had undergone 24-hour ambulatory double pH monitoring due to LPR-related symptoms. We analyzed the prevalence of LPR and numerous parameters from the 24-hour ambulatory double pH monitoring in the laryngeal cancer patient and control groups. Pathologic LPR is defined when more than three episodes of LPR occur in 24 hours.
Results: The prevalence of pathologic LPR was significantly higher in the laryngeal cancer group than the control group (P=0.049). The reflux number of the upper probe was significantly higher in the laryngeal cancer group (P<0.001). However the effects of pathologic LPR on laryngeal cancer risk were diluted after adjusting for smoking and alcohol consumption in the multivariable logistic regression.
Conclusion: The pathologic LPR might be a possible risk factor in the development of laryngeal cancer. A further study should be necessary to verify the exact role of LPR in laryngeal cancer.
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KEYWORD
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Regurgitation, Gastroesophageal reflux, 24-hour double pH monitoring, Laryngeal neoplasms
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